Skip to main content
SpringerLink
Log in

All GOD's creatures got dedicated mucosal immunity

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Mucosal IgA regulates the composition of gut microbiota. IgT in bony fish is now shown to have—via convergent evolution—the same properties as IgA, demonstrating strong evolutionary pressure to preserve both systemic and mucosal immunity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Properties of mucosal immunoglobulins among diverse vertebrate taxa.

References

  1. Danilova, N., Bussmann, J., Jekosch, K. & Steiner, L.A. Nat. Immunol. 6, 295–302 (2005).

    Article  CAS  PubMed Central  Google Scholar 

  2. Hansen, J.D., Landis, E.D. & Phillips R.B. Proc. Natl. Acad. Sci. USA 102, 6919–6924 (2005).

    Article  CAS  PubMed Central  Google Scholar 

  3. Zhang, Y.-A. et al. Nat. Immunol. 11, 827–835 (2010),

    Article  CAS  PubMed Central  Google Scholar 

  4. Portis, J.L. & Coe, J.E. Nature 258, 547–548 (1975).

    Article  CAS  PubMed Central  Google Scholar 

  5. Mussmann, R., Du Pasquier, L. & Hsu, E. Eur. J. Immunol. 26, 2823–2830 (1996).

    Article  CAS  PubMed Central  Google Scholar 

  6. Zhao, Y. et al. Proc. Natl. Acad. Sci. USA 103, 12087–12092 (2006).

    Article  CAS  PubMed Central  Google Scholar 

  7. Ohta, Y. & Flajnik M.F. Proc. Natl. Acad. Sci. USA 103, 10723–10728 (2006).

    Article  CAS  PubMed Central  Google Scholar 

  8. Mussmann, R. et al. Eur. J. Immunol. 26, 409–414 (1996).

    Article  CAS  PubMed Central  Google Scholar 

  9. Hooper, L.V. & Macpherson, A.J. Nat. Rev. Immunol. 10, 159–169 (2010).

    Article  CAS  PubMed Central  Google Scholar 

  10. Flajnik, M.F. Nat. Immunol. 6, 229–230 (2005).

    Article  CAS  PubMed Central  Google Scholar 

  11. Braathen, R., Hohman, V.S., Brandtzaeg, P. & Johansen, F.-E. J. Immunol. 178, 1589–1597 (2007).

    Article  CAS  PubMed Central  Google Scholar 

  12. Ye, J., Bromage, E.S. & Kaattari, S. L. J. Immunol. 184, 844–850 (2010).

    Article  CAS  PubMed Central  Google Scholar 

  13. Li, J. et al. Nat. Immunol. 7, 1116–1124 (2006).

    Article  CAS  Google Scholar 

  14. McFall-Ngai, M. Nature 445, 153 (2007).

    Article  CAS  PubMed Central  Google Scholar 

  15. Weaver, C.T. & Hatton, R.D. Nat. Rev. Immunol. 9, 883–889 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Martin F. Flajnik is in the Department of Microbiology and Immunology, University of Maryland at Baltimore, Baltimore, Maryland, USA.,

    Martin F Flajnik

Authors
  1. Martin F Flajnik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Martin F Flajnik.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Flajnik, M. All GOD's creatures got dedicated mucosal immunity. Nat Immunol 11, 777–779 (2010). https://doi.org/10.1038/ni0910-777

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0910-777

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation