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The complement receptor CD46 tips the scales in TH1 self-control

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The mechanisms driving IL-10 production by human T helper type 1 effector cells are poorly defined. New data link the complement regulator protein CD46 to this process and suggest an important role in autoimmune arthritis.

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Figure 1: CD46-mediated immunoregulation of TH1 and γδ T cells.

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Author notes

  1. joerg.koehl@uk-sh.de

  2. joerg.koehl@cchmc.org

Authors and Affiliations

  1. Christian M. Karsten is at the Institut für Systemische Entzündungsforschung, Universität zu Lübeck, Lübeck, Germany.,

    Christian M Karsten

  2. and in the Division of Molecular Immunology, Jörg Köhl is at the Institut für Systemische Entzündungsforschung, Universität zu Lübeck, Lübeck, Germany, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.,

    Jörg Köhl

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  1. Christian M Karsten
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  2. Jörg Köhl
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Correspondence to Jörg Köhl.

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The authors declare no competing financial interests.

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Karsten, C., Köhl, J. The complement receptor CD46 tips the scales in TH1 self-control. Nat Immunol 11, 775–777 (2010). https://doi.org/10.1038/ni0910-775

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