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Holding antigen where B cells can find it

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Specialized macrophage-like cells initiate antibody responses by trapping antigen in lymph. These antigen-trapping cells are located in the migration pathway of recirculating B cells, which can engage the trapped antigen.

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Figure 1: A working model for how B cells 'screen' antigen trapped on cells in the subcapsular sinus of lymph nodes.

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Authors and Affiliations

  1. Ian MacLennan is with the Medical Research Council Centre for Immune Regulation, The Institute of Biomedical Research, University of Birmingham, Birmingham B15 2TT, UK. i.c.m.maclennan@bham.ac.uk,

    Ian MacLennan

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  1. Ian MacLennan
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The author declares no competing financial interests.

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MacLennan, I. Holding antigen where B cells can find it. Nat Immunol 8, 909–910 (2007). https://doi.org/10.1038/ni0907-909

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