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Regula'ten' the gut

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Studies of genetically modified reporter mice have provided insight into the development of regulatory T cells. New work shows that regulatory T cells producing interleukin 10 arise in the periphery from Foxp3+ and Foxp3− thymic progenitors.

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Figure 1: The development of Treg cells in central and peripheral lymphoid organs.

Katie Ris-Vicari

References

  1. Moore, K.W., de Waal Malefyt, R., Coffman, R.L. & O'Garra, A. Annu. Rev. Immunol. 19, 683–765 (2001).

    Article  CAS  Google Scholar 

  2. Maynard, C.L. et al. Nat. Immunol. 8, 931–941 (2007).

    Article  CAS  Google Scholar 

  3. Calado, D.P., Paixao, T., Holmberg, D. & Haury, M. J. Immunol. 177, 5358–5364 (2006).

    Article  CAS  Google Scholar 

  4. Kamanaka, M. et al. Immunity 25, 941–952 (2006).

    Article  CAS  Google Scholar 

  5. Shoemaker, J., Saraiva, M. & O'Garra, A. J. Immunol. 176, 3470–3479 (2006).

    Article  CAS  Google Scholar 

  6. Kim, J.M. & Rudensky, A. Immunol. Rev. 212, 86–98 (2006).

    Article  CAS  Google Scholar 

  7. von Boehmer, H. J. Exp. Med. advance online publication, 9 July 2007 (doi:10.1084/jem.20071251) (2007).

  8. Coombes, J.L. et al. J. Exp. Med. advance online publication, 9 July 2007 (doi:10.1084/jem.20070590) (2007).

  9. Benson, M.J., Pino-Lagos, K., Rosemblatt, M. & Noelle, R.J. J. Exp. Med. advance online publication, 9 July 2007 (doi:10.1084/jem.20070719) (2007).

  10. Sun, C.M. et al. J. Exp. Med. advance online publication, 9 July 2007 (doi:10.1084/jem.20070602) (2007).

  11. Mucida, D. et al. Science 317, 256–260 (2007).

    Article  CAS  Google Scholar 

  12. Trinchieri, G. J. Exp. Med. 204, 239–243 (2007).

    Article  CAS  Google Scholar 

  13. O'Garra, A. & Vieira, P. Nat. Rev. Immunol. 7, 425–428 (2007).

    Article  CAS  Google Scholar 

  14. Roers, A. et al. J. Exp. Med. 200, 1289–1297 (2004).

    Article  CAS  Google Scholar 

  15. Maloy, K.J. et al. J. Exp. Med. 197, 111–119 (2003).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Paulo Vieira is with the Institut National de la Santé et de la Recherche Médicale U668 and Unité du Développement des Lymphocytes, Institut Pasteur, 75724 Paris Cedex 15, France.,

    Paulo Vieira

  2. Anne O'Garra is in the Division of Immunoregulation, The National Institute for Medical Research, London NW7 1AA, UK. aogarra@nimr.mrc.ac.uk,

    Anne O'Garra

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  1. Paulo Vieira
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  2. Anne O'Garra
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Vieira, P., O'Garra, A. Regula'ten' the gut. Nat Immunol 8, 905–907 (2007). https://doi.org/10.1038/ni0907-905

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