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Environmental conservation: bystander CD4 T cells keep CD8 memories fresh

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CD4+ T cells reportedly program CD8+ T cells to develop into suitable memory cells during the primary immune response. However, new data indicate that the maintenance of CD8+ memory T cells requires continuous exposure to bystander CD4+ T cells.

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Figure 1: Two models for the function of CD4+ T cells in the maintenance of CD8+ memory.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, 55455, Minnesota, USA

    Sara E Hamilton, Martin Prlic & Stephen C Jameson

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  1. Sara E Hamilton
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  2. Martin Prlic
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  3. Stephen C Jameson
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Hamilton, S., Prlic, M. & Jameson, S. Environmental conservation: bystander CD4 T cells keep CD8 memories fresh. Nat Immunol 5, 873–874 (2004). https://doi.org/10.1038/ni0904-873

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