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Location, location, location: the cell biology of immunoglobulin allelic control

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Individual lymphocytes express antigen receptors of a singular specificity. How this process, known as allelic exclusion, is established and maintained is unknown. Differences in subnuclear localization appear to contribute to enforcement of monoallelic receptor expression.

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Figure 1: Repositioning of Ig gene alleles upon B cell activation.

Bob Crimi

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Authors and Affiliations

  1. Department of Cell Biology, Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, 06520, CT, USA

    David G. T. Hesslein, Patrick E. Fields & David G. Schatz

Authors
  1. David G. T. Hesslein
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  2. Patrick E. Fields
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  3. David G. Schatz
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Hesslein, D., Fields, P. & Schatz, D. Location, location, location: the cell biology of immunoglobulin allelic control. Nat Immunol 2, 825–826 (2001). https://doi.org/10.1038/ni0901-825

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