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Autoimmune diseases: genes, bugs and failed regulation

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Abstract

In this Overview, common themes of the accompanying News & Views on RA, SLE, IDDM, thyroiditis and MS are discussed. A unifying concept for the development of these and other autoimmune diseases should incorporate genetic predisposition, environmental factors and immune dysregulation.

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Figure 1: Requirements for the development of an autoimmune disease.

Bob Crimi

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Authors and Affiliations

  1. Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, 94305, CA, USA

    Joerg Ermann & C. Garrison Fathman

Authors
  1. Joerg Ermann
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  2. C. Garrison Fathman
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Ermann, J., Fathman, C. Autoimmune diseases: genes, bugs and failed regulation. Nat Immunol 2, 759–761 (2001). https://doi.org/10.1038/ni0901-759

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