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Integrins limit the Toll

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Regulation of the inflammatory response is necessary for limiting tissue destruction and preventing autoimmunity. A recent discovery shows that CD11b activated by Toll-like receptors via inside-out signaling mediates degradation of the Toll-like receptor adaptors MyD88 and TRIF.

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Figure 1: Negative regulation of TLR signaling mediated by integrin CD11b in cells of the innate immune response.

Katie Vicari

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Authors and Affiliations

  1. Terry K. Means and Andrew D. Luster are with the Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.,

    Terry K Means & Andrew D Luster

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  1. Terry K Means
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  2. Andrew D Luster
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Correspondence to Andrew D Luster.

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The authors declare no competing financial interests.

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Means, T., Luster, A. Integrins limit the Toll. Nat Immunol 11, 691–693 (2010). https://doi.org/10.1038/ni0810-691

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