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One problem, two solutions

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Jawless fishes, the 'sister' group of jawed vertebrates, use leucine-rich repeat–containing proteins as antigen receptors. New work shows that the two isotypes of variable lymphocyte receptors are expressed in distinct lymphocyte lineages, which indicates that lymphocytes resembling T cells and B cells are an ancient feature of all vertebrates.

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Figure 1: Evolutionary history of key genetic elements of the adaptive immune systems in vertebrates.

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  1. Thomas Boehm is with the Max-Planck Institute of Immunobiology, Freiburg, Germany. boehm@immunbio.mpg.de,

    Thomas Boehm

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  1. Thomas Boehm
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Boehm, T. One problem, two solutions. Nat Immunol 10, 811–813 (2009). https://doi.org/10.1038/ni0809-811

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