Skip to main content

Advertisement

SpringerLink
Log in

Recognition reversal in a spineless scrounger

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

The recently deduced structures of amphioxus immune-like receptors provide new insights on what is actually required for antigen recognition by antigen receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Low-resolution representation of some key differences in domain-domain interactions for classical V domains and the amphioxus VCBP3 V1 and V2 V-like domains.

References

  1. Wu, T.T. & Kabat, E.A. J. Exp. Med. 132, 211–250 (1970).

    Article  CAS  Google Scholar 

  2. Poljak, R.J. Nature 256, 373–376 (1975).

    Article  CAS  Google Scholar 

  3. Hernández Prada, J.A. et al. Nat. Immunol. 7, 875–882 (2006).

    Article  Google Scholar 

  4. Kirkham, P.M. & Schroeder, H.W. Semin. Immunol. 6, 347–360 (1994).

    Article  CAS  Google Scholar 

  5. Hamers-Casterman, C. et al. Nature 363, 446–448 (1993).

    Article  CAS  Google Scholar 

  6. Cooper, M.D. & Alder, M.N. Cell 124, 815–822 (2006).

    Article  CAS  Google Scholar 

  7. Pancer, Z. et al. Nature 430, 174–180 (2004).

    Article  CAS  Google Scholar 

  8. Alder, M.N. et al. Science 310, 1970–1973 (2005).

    Article  CAS  Google Scholar 

  9. Pancer, Z., Mayer, W.E., Klein, J. & Cooper, M.D. Proc. Natl. Acad. Sci. USA 101, 13273–13278 (2004).

    Article  CAS  Google Scholar 

  10. Sun, S.C., Lindstrom, I., Boman, H.G., Faye, I. & Schmidt, O. Science 250, 1729–1732 (1990).

    Article  CAS  Google Scholar 

  11. Zhang, S.M., Adema, C.M., Kepler, T.B. & Loker, E.S. Science 305, 251–254 (2004).

    Article  CAS  Google Scholar 

  12. Watson, F.L. et al. Science 309, 1874–1878 (2005).

    Article  CAS  Google Scholar 

  13. Cannon, J.P., Haire, R.N. & Litman, G.W. Nat. Immunol. 3, 1200–1207 (2002).

    Article  CAS  Google Scholar 

  14. Silverman, G.J. & Goodyear, C.S. Nat. Rev. Immunol. 6, 465–475 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Case Western Reserve University, Cleveland, 44106, Ohio, USA

    Neil S Greenspan

  2. Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, 35294, Alabama, USA

    Harry W Schroeder Jr

Authors
  1. Neil S Greenspan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Harry W Schroeder Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Greenspan, N., Schroeder, H. Recognition reversal in a spineless scrounger. Nat Immunol 7, 797–798 (2006). https://doi.org/10.1038/ni0806-797

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0806-797

  • Springer Nature America, Inc.

Search

Navigation