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CD1d antigen presentation: treats for NKT cells

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Structural studies of CD1d presentation of α-galactosylceramide have shown that the lipid component fits snugly in the cleft, whereas the galactosyl head group protrudes upward, with key contact points between CD1d and the antigen conserved between mouse and human structures.

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Figure 1: Conserved antigen recognition by NKT cells despite species polymorphism in the presentation of α-GalCer by human and mouse CD1d.

Katie Ris

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Melbourne, Parkville, 3010, Victoria, Australia

    Dale I Godfrey & James McCluskey

  2. Department of Biochemistry and Molecular Biology, The Protein Crystallography Unit, School of Biomedical Sciences, Monash University, Clayton, 3800, Victoria, Australia

    Jamie Rossjohn

Authors
  1. Dale I Godfrey
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  2. James McCluskey
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  3. Jamie Rossjohn
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Godfrey, D., McCluskey, J. & Rossjohn, J. CD1d antigen presentation: treats for NKT cells. Nat Immunol 6, 754–756 (2005). https://doi.org/10.1038/ni0805-754

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