A handful of agonist peptide–MHC complexes can evoke a sustained signal from the T cell receptor. A combination of mathematical models and imaging experiments suggests a key function for CD4 and endogenous (self) peptides in the generation of this sensitive response.
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Hailman, E., Allen, P. Self help for T cells. Nat Immunol 5, 780–781 (2004). https://doi.org/10.1038/ni0804-780
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DOI: https://doi.org/10.1038/ni0804-780
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