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Catenin' on to nucleic acid sensing

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Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.

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Figure 1: The cytosolic protein LRRFIP1 can sense both RNA from viruses such as VSV and dsDNA from L. monocytogenes in myeloid cells.

Katherine A. Fitzgerald

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Authors and Affiliations

  1. Shruti Sharma and Katherine A. Fitzgerald are in the Division of Infectious Diseases and Immunology, Department of Medicine, Vijay A.K. Rathinam, University of Massachusetts Medical School, Worcester, Massachusetts, USA.,

    Vijay A K Rathinam, Shruti Sharma & Katherine A Fitzgerald

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  1. Vijay A K Rathinam
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  2. Shruti Sharma
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  3. Katherine A Fitzgerald
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Correspondence to Katherine A Fitzgerald.

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Rathinam, V., Sharma, S. & Fitzgerald, K. Catenin' on to nucleic acid sensing. Nat Immunol 11, 466–468 (2010). https://doi.org/10.1038/ni0610-466

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