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Multitasking in the medulla

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Medullary thymic epithelial cells maintain tolerance by expressing peripheral self antigens. New data show that they also present these antigens, which leads to the deletion of conventional CD4+ T cells and the induction of regulatory T cells.

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Figure 1: An avidity model of tolerance induction in the thymic medulla.

Kim Caesar

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Authors and Affiliations

  1. Ivan Dzhagalov and Ellen A. Robey are in the Department of Molecular and Cell Biology, Life Sciences Addition, University of California, Berkeley, California, USA.,

    Ivan Dzhagalov & Ellen A Robey

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  1. Ivan Dzhagalov
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  2. Ellen A Robey
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Correspondence to Ellen A Robey.

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The authors declare no competing financial interests.

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Dzhagalov, I., Robey, E. Multitasking in the medulla. Nat Immunol 11, 461–462 (2010). https://doi.org/10.1038/ni0610-461

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