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Manipulating hematopoietic stem cell amplification with Wnt

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The mechanisms that regulate self-renewal of hematopoietic stem cells have remained elusive. Recent papers in Nature point to an important role of the Wnt–β-catenin signaling pathway in promoting this process.

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Figure 1: A simplified model of HSC control.

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Authors and Affiliations

  1. Terry Fox Laboratory, British Columbia Cancer Agency and University of British Columbia, Vancouver, British Columbia, Canada

    Connie J Eaves

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  1. Connie J Eaves
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Eaves, C. Manipulating hematopoietic stem cell amplification with Wnt. Nat Immunol 4, 511–512 (2003). https://doi.org/10.1038/ni0603-511

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