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AIMing 2 defend against intracellular pathogens

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Intracellular pathogens face a diverse array of innate immune receptors. New data show that a single receptor, AIM2, functions to detect bacterial or viral DNA in the cytosol, inducing a protective inflammasome response.

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Figure 1: Endosomal and cytosolic pathways for pathogen detection.

Kim Caesar

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Authors and Affiliations

  1. Arthur M. Krieg is with Pfizer, Cambridge, Massachusetts, USA.,

    Arthur M Krieg

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  1. Arthur M Krieg
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Correspondence to Arthur M Krieg.

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The author declares competing financial interests: details accompany the full-text HTML version of the paper at http://www.nature.com/natureimmunology/.

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Krieg, A. AIMing 2 defend against intracellular pathogens. Nat Immunol 11, 367–369 (2010). https://doi.org/10.1038/ni0510-367

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