Skip to main content

Advertisement

Log in

Contact hypersensitivity: not just T cells!

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Contact hypersensitivity is a form of delayed-type hypersensitivity, a classic T cell–mediated, clinically important phenomenon. Unexpectedly, a new study indicates that natural killer cells may mediate contact hypersensitivity and demonstrate adaptive, memory-like activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Key evidence supporting involvement of NK cells in CHS.

Katie Ris

References

  1. O'Leary, J.G., Goodarzi, M., Drayton, D.L. & von Andrian, U.H. Nat. Immunol. 7, 507–516 (2006).

    Article  CAS  Google Scholar 

  2. Belsito, D.V. Allergic contact dermatitis. In Fitzpatrick's Dermatology in General Medicine 5th edn. (eds. Freedberg, I.M. et al.) 1447–1461 (McGraw-Hill, New York, 1999).

    Google Scholar 

  3. Janeway, C.A., Jr., Travers, P., Walport, M. & Shlomchik, M. Immunobiology. The Immune System in Health and Disease 5th edn. (Garland, New York, 2001).

    Google Scholar 

  4. Yokoyama, W.M. Natural killer cells. In Fundamental Immunology 4th edn. (ed. Paul, W.E.) Ch. 17, 575–603 (Lippincott-Raven, New York, 1999).

    Google Scholar 

  5. Dokun, A.O. et al. Nat. Immunol. 2, 951–956 (2001).

    Article  CAS  Google Scholar 

  6. Martin-Fontecha, A. et al. Nat. Immunol. 5, 1260–1265 (2004).

    Article  CAS  Google Scholar 

  7. Koka, R. et al. J. Exp. Med. 197, 977–984 (2003).

    Article  CAS  Google Scholar 

  8. Bauer, S. et al. Science 285, 727–729 (1999).

    Article  CAS  Google Scholar 

  9. Grabbe, S. et al. J. Clin. Invest. 98, 1158–1164 (1996).

    Article  CAS  Google Scholar 

  10. Wu, J. et al. Science 285, 730–732 (1999).

    Article  CAS  Google Scholar 

  11. Diefenbach, A. et al. Nat. Immunol. 3, 1142–1149 (2002).

    Article  CAS  Google Scholar 

  12. Kim, S. et al. Nature 436, 709–713 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yokoyama, W. Contact hypersensitivity: not just T cells!. Nat Immunol 7, 437–439 (2006). https://doi.org/10.1038/ni0506-437

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0506-437

  • Springer Nature America, Inc.

This article is cited by

Navigation