Contact hypersensitivity is a form of delayed-type hypersensitivity, a classic T cell–mediated, clinically important phenomenon. Unexpectedly, a new study indicates that natural killer cells may mediate contact hypersensitivity and demonstrate adaptive, memory-like activity.
References
O'Leary, J.G., Goodarzi, M., Drayton, D.L. & von Andrian, U.H. Nat. Immunol. 7, 507–516 (2006).
Belsito, D.V. Allergic contact dermatitis. In Fitzpatrick's Dermatology in General Medicine 5th edn. (eds. Freedberg, I.M. et al.) 1447–1461 (McGraw-Hill, New York, 1999).
Janeway, C.A., Jr., Travers, P., Walport, M. & Shlomchik, M. Immunobiology. The Immune System in Health and Disease 5th edn. (Garland, New York, 2001).
Yokoyama, W.M. Natural killer cells. In Fundamental Immunology 4th edn. (ed. Paul, W.E.) Ch. 17, 575–603 (Lippincott-Raven, New York, 1999).
Dokun, A.O. et al. Nat. Immunol. 2, 951–956 (2001).
Martin-Fontecha, A. et al. Nat. Immunol. 5, 1260–1265 (2004).
Koka, R. et al. J. Exp. Med. 197, 977–984 (2003).
Bauer, S. et al. Science 285, 727–729 (1999).
Grabbe, S. et al. J. Clin. Invest. 98, 1158–1164 (1996).
Wu, J. et al. Science 285, 730–732 (1999).
Diefenbach, A. et al. Nat. Immunol. 3, 1142–1149 (2002).
Kim, S. et al. Nature 436, 709–713 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yokoyama, W. Contact hypersensitivity: not just T cells!. Nat Immunol 7, 437–439 (2006). https://doi.org/10.1038/ni0506-437
Issue Date:
DOI: https://doi.org/10.1038/ni0506-437
- Springer Nature America, Inc.
This article is cited by
-
Hidden talents of natural killers: NK cells in innate and adaptive immunity
EMBO reports (2009)