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Toll signaling: RIPping off the TNF pathway

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Toll-like receptors (TLRs) use multiple downstream signaling pathways. New data suggest that components of the tumor necrosis factor receptor signaling pathway are involved in signal transduction by certain TLR family members.

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Figure 1: Signaling pathways downstream of the TLR adaptor Trif.

K.R.

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Barton, G., Medzhitov, R. Toll signaling: RIPping off the TNF pathway. Nat Immunol 5, 472–474 (2004). https://doi.org/10.1038/ni0504-472

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