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Maturation of effector regulatory T cells

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Regulatory T cells adopt specialized differentiation programs controlled by transcription factors. The transcription factors Blimp-1 and IRF4 are now shown to be pivotal in the maturation of effector regulatory T cells.

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Figure 1: Control of the effector function of Treg cells by transcription factors.

References

  1. Sakaguchi, S. et al. Cell 133, 775–787 (2008).

    Article  CAS  Google Scholar 

  2. Koch, M.A. et al. Nat. Immunol. 10, 595–602 (2009).

    Article  CAS  Google Scholar 

  3. Zheng, Y. et al. Nature 458, 351–356 (2009).

    Article  CAS  Google Scholar 

  4. Cretney, E. et al. Nat. Immunol. 12, 304–311 (2011).

    Article  CAS  Google Scholar 

  5. Nutt, S.L. et al. Nat. Rev. Immunol. 7, 923–927 (2007).

    Article  CAS  Google Scholar 

  6. Martins, G.A. et al. Nat. Immunol. 7, 457–465 (2006).

    Article  CAS  Google Scholar 

  7. Zheng, Y. et al. Nature 445, 936–940 (2007).

    Article  CAS  Google Scholar 

  8. Kallies, A. et al. Nat. Immunol. 7, 466–474 (2006).

    Article  CAS  Google Scholar 

  9. Ono, M. et al. Nature 446, 685–689 (2007).

    Article  CAS  Google Scholar 

  10. Ouyang, W. et al. Nat. Immunol. 11, 618–627 (2010).

    Article  CAS  Google Scholar 

  11. Pan, F. et al. Science 325, 1142–1146 (2009).

    Article  CAS  Google Scholar 

  12. Wu, Y. et al. Cell 126, 375–387 (2006).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Naganari Ohkura and Shimon Sakaguchi are in the Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan,

    Naganari Ohkura & Shimon Sakaguchi

  2. World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan

    Naganari Ohkura & Shimon Sakaguchi

Authors
  1. Naganari Ohkura
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  2. Shimon Sakaguchi
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Correspondence to Shimon Sakaguchi.

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The authors declare no competing financial interests.

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Ohkura, N., Sakaguchi, S. Maturation of effector regulatory T cells. Nat Immunol 12, 283–284 (2011). https://doi.org/10.1038/ni0411-283

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