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Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance

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The transcriptional regulators Foxp3 and Aire have key functions in self-tolerance. New studies emphasize potential links between Aire-expressing thymic stromal cells and the development of Foxp3-expressing regulatory T cells.

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Figure 1: Interactions between developing thymocytes and thymic stromal cells, in particular Aire-expressing mTECs, may drive thymocytes into the Treg cell lineage.

Kim Caesar

References

  1. Lin, W. et al. Nat. Immunol. 8, 359–368 (2007).

    Article  CAS  Google Scholar 

  2. Gavin, M.A. et al. Nature 445, 771–775 (2007).

    Article  CAS  Google Scholar 

  3. Aschenbrenner, K. et al. Nat. Immunol. 8, 351–358 (2007).

    Article  CAS  Google Scholar 

  4. Hori, S., Nomura, T. & Sakaguchi, S. Science 299, 1057–1061 (2003).

    Article  CAS  Google Scholar 

  5. Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Nat. Immunol. 4, 330–336 (2003).

    Article  CAS  Google Scholar 

  6. Khattri, R., Cox, T., Yasayko, S.A. & Ramsdell, F. Nat. Immunol. 4, 337–342 (2003).

    Article  CAS  Google Scholar 

  7. Sakaguchi, S. et al. Immunol. Rev. 212, 8–27 (2006).

    Article  CAS  Google Scholar 

  8. Su, M.A. & Anderson, M.S. Curr. Opin. Immunol. 16, 746–752 (2004).

    Article  CAS  Google Scholar 

  9. Gallegos, A.M. & Bevan, M.J. J. Exp. Med. 200, 1039–1049 (2004).

    Article  CAS  Google Scholar 

  10. Watanabe, N. et al. Nature 436, 1181–1185 (2005).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Takashi Nomura and Shimon Sakaguchi are in the Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. shimon@frontier.kyoto-u.ac.jp,

    Takashi Nomura & Shimon Sakaguchi

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  1. Takashi Nomura
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  2. Shimon Sakaguchi
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The authors declare no competing financial interests.

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Nomura, T., Sakaguchi, S. Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance. Nat Immunol 8, 333–334 (2007). https://doi.org/10.1038/ni0407-333

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