Skip to main content

Advertisement

SpringerLink
Log in

Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1?

  • Commentary
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Abstract

Most people infected with human immunodeficiency virus 2 (HIV-2) do not progress to disease, even though the minority who do cannot be distinguished clinically from HIV-1-infected patients. Here we review what is known about the basis of viral control in HIV-2 infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Gao, F. et al. Nature 397, 436–441 (1999).

    Article  CAS  Google Scholar 

  2. Brenchley, J.M. et al. J. Exp. Med. 200, 749–759 (2004).

    Article  CAS  Google Scholar 

  3. Brenchley, J.M. et al. Nat. Med. 12, 1365–1371 (2006).

    Article  CAS  Google Scholar 

  4. Clavel, F. et al. Science 233, 343–346 (1986).

    Article  CAS  Google Scholar 

  5. Martinez-Steele, E. et al. AIDS 21, 317–324 (2007).

    Article  Google Scholar 

  6. Poulsen, A.G. et al. Lancet 349, 911–914 (1997).

    Article  CAS  Google Scholar 

  7. Darby, S.C. et al. Nature 377, 79–82 (1995).

    Article  CAS  Google Scholar 

  8. Popper, S.J. et al. J. Virol. 74, 1554–1557 (2000).

    Article  CAS  Google Scholar 

  9. Berry, N. et al. AIDS Res. Hum. Retroviruses 18, 1167–1173 (2002).

    Article  Google Scholar 

  10. Grassly, N.C. et al. J. Virol. 72, 7895–7899 (1998).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Ota, M.O. et al. AIDS 14, 435–439 (2000).

    Article  CAS  Google Scholar 

  12. Ribeiro, A.C. et al. J. Virol. 79, 823–833 (2005).

    Article  CAS  Google Scholar 

  13. Ylinen, L.M., Keckesova, Z., Wilson, S.J., Ranasinghe, S. & Towers, G.J. J. Virol. 79, 11580–11587 (2005).

    Article  CAS  Google Scholar 

  14. Rowland-Jones, S.L. et al. Nat. Med. 1, 59–64 (1995).

    Article  Google Scholar 

  15. Jaye, A. et al. J. Infect. Dis. 189, 498–505 (2004).

    Article  Google Scholar 

  16. Zheng, N.N. et al. J. Virol. 78, 13934–13942 (2004).

    Article  CAS  Google Scholar 

  17. Lopes, A.R. et al. J. Immunol. 171, 307–316 (2003).

    Article  CAS  Google Scholar 

  18. Gillespie, G.M. et al. Eur. J. Immunol. 35, 1445–1453 (2005).

    Article  CAS  Google Scholar 

  19. Duvall, M.G. et al. J. Immunol. 176, 6973–6981 (2006).

    Article  CAS  Google Scholar 

  20. Douek, D.C. et al. Nature 417, 95–98 (2002).

    Article  CAS  Google Scholar 

  21. Nuvor, S.V., van der Sande, M., Rowland-Jones, S., Whittle, H. & Jaye, A. J. Virol. 80, 2529–2538 (2006).

    Article  CAS  Google Scholar 

  22. Weiss, R.A. et al. AIDS 2, 95–100 (1988).

    Article  CAS  Google Scholar 

  23. Travers, K. et al. Science 268, 1612–1615 (1995).

    Article  CAS  Google Scholar 

  24. Schim van der Loeff, M.F. et al. AIDS 15, 2303–10 (2001).

    Article  CAS  Google Scholar 

  25. Silvestri, G. et al. Immunity 18, 441–452 (2003).

    Article  CAS  Google Scholar 

  26. Jaffar, S. et al. AIDS Res. Hum. Retroviruses 21, 560–564 (2005).

    Article  CAS  Google Scholar 

  27. Sousa, A.E., Carneiro, J., Meier-Schellersheim, M., Grossman, Z. & Victorino, R.M. J. Immunol. 169, 3400–3406 (2002).

    Article  CAS  Google Scholar 

  28. Schindler, M. et al. Cell 125, 1055–1067 (2006).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sarah L. Rowland-Jones and Hilton C. Whittle are with the Medical Research Council Laboratories, Fajara, the Gambia, West Africa. srowland-jones@mrc.gm,

    Sarah L Rowland-Jones & Hilton C Whittle

Authors
  1. Sarah L Rowland-Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hilton C Whittle
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rowland-Jones, S., Whittle, H. Out of Africa: what can we learn from HIV-2 about protective immunity to HIV-1?. Nat Immunol 8, 329–331 (2007). https://doi.org/10.1038/ni0407-329

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0407-329

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation