Different peptide antigens induce T cell repertoires of very different diversity. An analysis of the effect on T cell receptor usage of re-engineering peptide features indicates that a lack of prominent side chains presented for recognition limits the T cell repertoire.
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Katie Ris
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Jones, E. Favorite flavors of surfaces. Nat Immunol 6, 365–366 (2005). https://doi.org/10.1038/ni0405-365
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DOI: https://doi.org/10.1038/ni0405-365
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