Skip to main content
SpringerLink
Log in

Knowing one's self: central tolerance revisited

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Tissue-specific antigens are expressed in the thymic medulla under the influence of the AIRE gene, suggesting that unresponsiveness to these peripheral antigens is a result of central tolerance. New data on T cell tolerance in AIRE−/− mice strongly support this hypothsis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Presentation of self-proteins by bone marrow–derived APCs versus MECs for tolerance induction in the thymus.

C.C.

References

  1. Stockinger, B. Adv. Immunol. 71, 229–265 (1999).

    Article  CAS  Google Scholar 

  2. Kyewski, B., Derbinski, J., Gotter, J. & Klein, L. Trends Immunol. 23, 364–371 (2002).

    Article  CAS  Google Scholar 

  3. Sprent, J. & Kishimoto, H. Immunol. Rev. 185, 126–135 (2002).

    Article  CAS  Google Scholar 

  4. Bjorses, P. et al. Am. J. Hum. Genet. 66, 378–392 (2000).

    Article  CAS  Google Scholar 

  5. Ramsey, C. et al. Hum Mol Genet. 11, 397–409 (2002).

    Article  CAS  Google Scholar 

  6. Anderson, M.S. et al. Science 298, 1395–1401 (2002).

    Article  CAS  Google Scholar 

  7. Liston, P., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C.C. Nat. Immunol. 4, 350–354 (2003).

    Article  CAS  Google Scholar 

  8. Heath, W.R., Karamalis, F., Donoghue, J. & Miller, J.F. J. Immunol. 155, 2339–2349 (1995).

    CAS  PubMed  Google Scholar 

  9. Surh, C.D. & Sprent, J. Microbes Infect. 4, 51–56 (2002).

    Article  CAS  Google Scholar 

  10. Jordan, M.S. et al. Nat. Immunol. 2, 301–306 (2001).

    Article  CAS  Google Scholar 

  11. Sprent, J., Kosaka, H., Gao, E.K., Surh, C.D. & Webb, S.R. Immunol. Rev. 133, 151–176 (1993).

    Article  CAS  Google Scholar 

  12. Hammerling, G.J., Schonrich, G., Ferber, I. & Arnold, B. Immunol. Rev. 133, 93–104 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, IMM4, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, 92037, California

    Jonathan Sprent & Charles D. Surh

Authors
  1. Jonathan Sprent
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles D. Surh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jonathan Sprent.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sprent, J., Surh, C. Knowing one's self: central tolerance revisited. Nat Immunol 4, 303–304 (2003). https://doi.org/10.1038/ni0403-303

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0403-303

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation