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Developing NKT cells need their calcium

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Although the development of natural killer T cells is a T cell antigen receptor–dependent process, the signaling pathways involved are poorly defined. New data demonstrate that the calcineurin–transcription factor NFAT pathway exerts a critical influence on this process by controlling the transcription factor Egr2.

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Figure 1: The function of calcineurin, NFAT and Egr proteins in the development of NKT cells and conventional T cells.

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Authors and Affiliations

  1. Dale I. Godfrey and Sanda Stankovic are in the Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria 3010, Australia.,

    Dale I Godfrey & Sanda Stankovic

  2. Alan G. Baxter is in the Comparative Genomics Centre, James Cook University, Townsville QLD 4811, Australia. godfrey@unimelb.edu.au,

    Alan G Baxter

Authors
  1. Dale I Godfrey
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  2. Sanda Stankovic
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  3. Alan G Baxter
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Godfrey, D., Stankovic, S. & Baxter, A. Developing NKT cells need their calcium. Nat Immunol 10, 231–233 (2009). https://doi.org/10.1038/ni0309-231

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