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Act1-ivating IL-17 inflammation

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The signaling adaptor Act1 is now shown in vivo to be essential for interleukin 17–mediated inflammation in the brain during experimental autoimmune encephalomyelitis and in gut epithelial cells during induced colitis.

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Figure 1: IL-17R signaling requires Act1.

Katie Ris

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Authors and Affiliations

  1. Christopher A. Hunter is with the University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania 19104-4539, USA. chunter@vet.upenn.edu,

    Christopher A Hunter

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  1. Christopher A Hunter
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Hunter, C. Act1-ivating IL-17 inflammation. Nat Immunol 8, 232–234 (2007). https://doi.org/10.1038/ni0307-232

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