Autophagy has been linked to inflammatory bowel disease. Studies of two different mouse strains deficient in the autophagy-related gene product Atg16L1 now show that autophagy is important in regulating the secretory function of Paneth cells and the production of inflammatory cytokines in the intestine.
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Katie Vicari
References
Xavier, R.J. & Podolsky, D.K. Nature 448, 427–434 (2007).
Cadwell, K. et al. Nature 456, 259–264 (2008).
Saitoh, T. et al. Nature 456, 264–269 (2008).
Levine, B. & Deretic, V. Nat. Rev. Immunol. 7, 767–777 (2007).
Hampe, J. et al. Nat. Genet. 39, 207–211 (2007).
Kanneganti, T.-D., Lamkanfi, M. & Núñez, G. Immunity 27, 549–559 (2007).
Maeda, S. et al. Science 307, 734–738 (2005).
Xu, Y. et al. Immunity 27, 135–144 (2007).
Delgado, M.A., Elmaoued, R.A., Davis, A.S., Kyei, G. & Deretic, V. EMBO J. 27, 1110–1121 (2008).
Levine, B. & Kroemer, G. Cell 132, 27–42 (2008).
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Yano, T., Kurata, S. An unexpected twist for autophagy in Crohn's disease. Nat Immunol 10, 134–136 (2009). https://doi.org/10.1038/ni0209-134
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DOI: https://doi.org/10.1038/ni0209-134
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