Suppressor of cytokine signaling 1 has been linked to the negative regulation of Toll-like receptor signaling. The mechanism for this seems to be suppressor of cytokine signaling 1–mediated degradation of the adaptor Mal, which is required for Toll-like receptor signaling.
This is a preview of subscription content, log in via an institution to check access.
Katie Ris
References
Akira, S. & Takeda, K. Nat. Rev. Immunol. 4, 499–511 (2004).
Mansell, A. et al. Nat. Immunol. 7, 148–155 (2006).
Han, H. & Ulevitch, R. Nat. Immunol. 6, 1198–1205 (2005).
Naka, T., Fujimoto, M., Tsutsui, H. & Yoshimura, A. Adv. Immunol. 87, 61–122 (2005).
Kamura, T. et al. Genes Dev. 18, 3055–3065 (2004).
Kinjyo, I. et al. Immunity 17, 583–591 (2002).
Nakagawa, R. et al. Immunity 17, 677–687 (2002).
Yamin, T.T. & Miller, D.K. J. Biol. Chem. 272, 21540–21547 (1997).
Ryo, A. et al. Mol. Cell 12, 1413–1426 (2003).
Doyle, S.L. Jefferies, C.A. & O'Neill, L.A. J. Biol. Chem. 280, 23496–23501 (2005).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kobayashi, T., Takaesu, G. & Yoshimura, A. Mal-function of TLRs by SOCS. Nat Immunol 7, 123–124 (2006). https://doi.org/10.1038/ni0206-123
Issue Date:
DOI: https://doi.org/10.1038/ni0206-123
- Springer Nature America, Inc.
This article is cited by
-
Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells
Mucosal Immunology (2016)
-
Increased Pro-inflammatory Cytokine Production After Lipopolysaccharide Stimulation in Patients with X-linked Agammaglobulinemia
Journal of Clinical Immunology (2012)