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Cooperative regulatory events and Foxp3 expression

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The molecular mechanisms that control Treg and TH17 development and the precise role of TGF-β in this process are complex and imperfectly understood. New findings indicate that the helix-loop-helix proteins E2A and Id3 are also critically involved in some of these processes.

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Figure 1: Transcriptional regulation of Foxp3.

References

  1. Maruyama, T. et al. Nat. Immunol. 12, 86–95 (2011).

    Article  CAS  Google Scholar 

  2. Zhou, L. et al. Nature 453, 236–240 (2008).

    Article  CAS  Google Scholar 

  3. Murre, C. Nat. Immunol. 6, 1079–1086 (2005).

    Article  CAS  Google Scholar 

  4. Mantel, P.Y. et al. PLoS Biol. 5, e329 (2007).

    Article  Google Scholar 

  5. Takimoto, T. et al. J. Immunol. 185, 842–855 (2010).

    Article  CAS  Google Scholar 

  6. Tone, Y. et al. Nat. Immunol. 9, 194–202 (2008).

    Article  CAS  Google Scholar 

  7. Samon, J.B. et al. Blood 112, 1813–1821 (2008).

    Article  CAS  Google Scholar 

  8. Zheng, Y. et al. Nature 463, 808–812 (2010).

    Article  CAS  Google Scholar 

  9. Kim, H.P. & Leonard, W.J. J. Exp. Med. 204, 1543–1551 (2007).

    Article  CAS  Google Scholar 

  10. Xu, L. et al. Immunity 33, 313–325 (2010).

    Article  CAS  Google Scholar 

  11. Wu, Y. et al. Cell 126, 375–387 (2006).

    Article  CAS  Google Scholar 

  12. Li, B. et al. Proc. Natl. Acad. Sci. USA 104, 4571–4576 (2007).

    Article  CAS  Google Scholar 

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Author notes

  1. masahide.tone@csmc.edu

Authors and Affiliations

  1. Masahide Tone is in the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.,

    Masahide Tone

  2. Mark I. Greene is in the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.,

    Mark I Greene

Authors
  1. Masahide Tone
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  2. Mark I Greene
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The authors declare no competing financial interests.

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Tone, M., Greene, M. Cooperative regulatory events and Foxp3 expression. Nat Immunol 12, 14–16 (2011). https://doi.org/10.1038/ni0111-14

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