Skip to main content

Advertisement

SpringerLink
Log in

Fine tuning NF-κB: new openings for PKC-ζ

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

NF-κB is a critical transcription factor that is regulated by several post-transcriptional modifications. The characterization of their roles would help in the design of new therapeutic targets in cancer and inflammation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: PKC-ζ-mediated phosphorylation of RelA regulates transcription.

References

  1. Ghosh, S. & Hayden, M.S. Nat. Rev. Immunol. 8, 837–848 (2008).

    Article  CAS  Google Scholar 

  2. Levy, D. et al. Nat. Immunol. 12, 29–36 (2010).

    Article  Google Scholar 

  3. Zhong, H., May, M.J., Jimi, E. & Ghosh, S. Mol. Cell 9, 625–636 (2002).

    Article  CAS  Google Scholar 

  4. Chen, L.F. et al. Mol. Cell. Biol. 25, 7966–7975 (2005).

    Article  CAS  Google Scholar 

  5. Duran, A., Diaz-Meco, M.T. & Moscat, J. EMBO J. 22, 3910–3918 (2003).

    Article  CAS  Google Scholar 

  6. Leitges, M. et al. Mol. Cell 8, 771–780 (2001).

    Article  CAS  Google Scholar 

  7. Karin, M. Nature 441, 431–436 (2006).

    Article  CAS  Google Scholar 

  8. Tachibana, M., Matsumura, Y., Fukuda, M., Kimura, H. & Shinkai, Y. EMBO J. 27, 2681–2690 (2008).

    Article  CAS  Google Scholar 

  9. Moscat, J., Diaz-Meco, M.T. & Wooten, M.W. Cell Death Differ. 16, 1426–1437 (2009).

    Article  CAS  Google Scholar 

  10. De Santa, F. et al. Cell 130, 1083–1094 (2007).

    Article  CAS  Google Scholar 

  11. Lallena, M.J., Diaz-Meco, M.T., Bren, G., Pay, C.V. & Moscat, J. Mol. Cell. Biol. 19, 2180–2188 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jorge Moscat and Maria T. Diaz-Meco are at the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.,

    Jorge Moscat & Maria T Diaz-Meco

Authors
  1. Jorge Moscat
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria T Diaz-Meco
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jorge Moscat.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moscat, J., Diaz-Meco, M. Fine tuning NF-κB: new openings for PKC-ζ. Nat Immunol 12, 12–14 (2011). https://doi.org/10.1038/ni0111-12

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni0111-12

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation