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Defensins keep the peace too

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The mammalian intestine contains a large number of commensal bacterial strains. New work suggests that antimicrobial peptides used for defense against pathogenic bacteria are also used to adjust the balance among bacterial populations and to control intestinal homeostasis.

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Figure 1: HD5 regulates intestinal SFB colonization and the development of mucosal TH17 cells in homozygous DEFA5-transgenic mice1.

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Authors and Affiliations

  1. Alfredo Menendez, Rosana B.R. Ferreira and B. Brett Finlay are in the Michael Smith Laboratories at The University of British Columbia, Vancouver, Canada.,

    Alfredo Menendez, Rosana B R Ferreira & B Brett Finlay

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  1. Alfredo Menendez
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  2. Rosana B R Ferreira
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  3. B Brett Finlay
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Correspondence to B Brett Finlay.

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Menendez, A., Ferreira, R. & Brett Finlay, B. Defensins keep the peace too. Nat Immunol 11, 49–50 (2010). https://doi.org/10.1038/ni0110-49

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