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A new function for the RNA-editing enzyme ADAR1

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ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.

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Figure 1: A-to-I RNA editing of an as-yet-unknown dsRNA by ADAR1 is required for the maintenance of HSCs.

Katie Vicari

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Authors and Affiliations

  1. Hisashi Iizasa and Kazuko Nishikura are in the Department of Gene Expression and Regulation, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA. kazuko@wistar.org,

    Hisashi Iizasa & Kazuko Nishikura

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  1. Hisashi Iizasa
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  2. Kazuko Nishikura
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Iizasa, H., Nishikura, K. A new function for the RNA-editing enzyme ADAR1. Nat Immunol 10, 16–18 (2009). https://doi.org/10.1038/ni0109-16

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