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From immunity to tolerance through HDAC

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Regulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in CD4+ T cells.

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Figure 1: A model of how the function of antigen-presenting cells is regulated by HDAC11 through Il10.

Katie Vicari

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Authors and Affiliations

  1. Katia Georgopoulos is with the Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. katia.georgopoulos@cbrc2.mgh.harvard.edu,

    Katia Georgopoulos

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  1. Katia Georgopoulos
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Georgopoulos, K. From immunity to tolerance through HDAC. Nat Immunol 10, 13–14 (2009). https://doi.org/10.1038/ni0109-13

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