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How resting T cells deMURR HIV infection

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Murr1, a protein linked to copper homeostasis, is shown in a recent Nature paper to inhibit the degradation of IκBα. This unexpected action of Murr1, which blunts both basal and stimulus-coupled activation of the NF-κB transcription factor, is key in making resting CD4 T lymphocytes nonpermissive for HIV infection.

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Figure 1: Interaction of Murr1 with IκBα through its ankyrin repeat domain and with the cullin1 component of the E3 ligase complex (β-TrCP1–Skp1–Cul1–Rbx1–E2-Ub), which mediates the polyubiquitylation of phospho-IκBα.

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  1. Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, 94141, California, USA

    Warner C Greene

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  1. Warner C Greene
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Greene, W. How resting T cells deMURR HIV infection. Nat Immunol 5, 18–19 (2004). https://doi.org/10.1038/ni0104-18

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