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Feeling stressed? It might be your T cells

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A Publisher Correction to this article was published on 28 June 2018

Abolishing signals mediated by the inhibitory receptor PD-1 results in a systemic decrease in tryptophan and tyrosine, which leads to a striking deficiency in the neurotransmitters serotonin and dopamine in the brain and anxiety-like behavior and exacerbated fear.

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Figure 1: Compromising CNS functions by PD-1 ablation.

Kim Caesar/Springer Nature

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Authors and Affiliations

  1. Division of Hematology-Oncology and Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

    Laura Strauss, Nikolaos Patsoukis & Vassiliki A Boussiotis

Authors
  1. Laura Strauss
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  2. Nikolaos Patsoukis
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  3. Vassiliki A Boussiotis
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Corresponding author

Correspondence to Vassiliki A Boussiotis.

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Competing interests

V.A.B. holds patents on the PD-1 pathway licensed by Bristol-Myers Squibb, Roche, Merck, EMDSerono, Boehringer Ingelheim, AstraZeneca, Novartis and Dako.

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Strauss, L., Patsoukis, N. & Boussiotis, V. Feeling stressed? It might be your T cells. Nat Immunol 18, 1281–1283 (2017). https://doi.org/10.1038/ni.3872

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