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Suppression from beyond the grave

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Adenosine produced by apoptotic regulatory T cells (Treg cells) has a more important immunosuppressive role in the tumor microenvironment than that of live Treg cells. This discovery raises the possibility of novel strategies for cancer immunotherapy.

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Figure 1: Immunosuppressive mechanisms of apoptotic and living Treg cells.

Kim Caesar/Springer Nature

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Authors and Affiliations

  1. Division of Cancer Immunology, Research Institute/EPOC, National Cancer Center, Tokyo, Japan

    Yosuke Togashi

  2. Division of Cancer Immunology, Research Institute/EPOC, National Cancer Center, Tokyo, Japan

    Hiroyoshi Nishikawa

  3. Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Hiroyoshi Nishikawa

Authors
  1. Yosuke Togashi
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  2. Hiroyoshi Nishikawa
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Corresponding author

Correspondence to Hiroyoshi Nishikawa.

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The authors declare no competing financial interests.

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Togashi, Y., Nishikawa, H. Suppression from beyond the grave. Nat Immunol 18, 1285–1286 (2017). https://doi.org/10.1038/ni.3870

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