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TFR cells trump autoimmune antibody responses to limit sedition

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The differentiation of follicular regulatory T cells can be limited by the cytokine IL-2, preventing the emergence of autoantibodies. This research identifies these cells as key regulators of the germinal center response.

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Figure 1: IL-2 signaling inhibits the differentiation of TFR cells.

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Authors and Affiliations

  1. Lymphocyte Signaling and Development, Babraham Institute, Cambridge, UK

    Michelle A Linterman

  2. Institute for Immunology and Immunotherapy, University of Birmingham Medical School, Birmingham, UK

    Kai-Michael Toellner

Authors
  1. Michelle A Linterman
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  2. Kai-Michael Toellner
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Correspondence to Michelle A Linterman.

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The authors declare no competing financial interests.

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Linterman, M., Toellner, KM. TFR cells trump autoimmune antibody responses to limit sedition. Nat Immunol 18, 1185–1186 (2017). https://doi.org/10.1038/ni.3856

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