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IFN-λ 'guts' neutrophil-mediated inflammation

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Interferon-λ (IFN-λ) curbs neutrophil-mediated intestinal inflammation by diminishing the production of reactive oxygen species and subsequent oxidative stress. This regulatory process is unique to IFN-λ and is independent of interferon-induced transcription and translation programs.

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Figure 1: IFN-λ produced in response to enteric viruses regulates intestinal inflammation via diminishing neutrophil function.

Kim Caesar/Springer Nature

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Authors and Affiliations

  1. Department of Immunology, University of Washington, Seattle, Washington, USA

    Emily A Hemann, Johannes Schwerk & Ram Savan

Authors
  1. Emily A Hemann
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  2. Johannes Schwerk
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  3. Ram Savan
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Correspondence to Ram Savan.

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The authors declare no competing financial interests.

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Hemann, E., Schwerk, J. & Savan, R. IFN-λ 'guts' neutrophil-mediated inflammation. Nat Immunol 18, 1061–1062 (2017). https://doi.org/10.1038/ni.3834

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