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Untangling Fc and complement receptors to kill tumors

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Uncoupling of activation of Fc receptors via a mutant IgG1 Fc domain shows a direct role for complement receptors in antibody-dependent tumor killing.

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Figure 1: The various mechanisms by which antibodies can induce tumor killing.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. Program in Cellular and Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA

    Cees E van der Poel & Michael C Carroll

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  1. Cees E van der Poel
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  2. Michael C Carroll
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Correspondence to Michael C Carroll.

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The authors declare no competing financial interests.

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van der Poel, C., Carroll, M. Untangling Fc and complement receptors to kill tumors. Nat Immunol 18, 874–875 (2017). https://doi.org/10.1038/ni.3797

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