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A Hippo in the Fox(p3) house

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The Hippo signaling pathway regulates cellular proliferation and survival during tissue growth and cancer. In CD4+ T cells, members of the Hippo family modulate autoimmune inflammation by altering interactions between the transcription factors Foxp3 and RORγt; this reveals an unexpected non-canonical role for Hippo in adaptive immunity.

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Figure 1: Regulation of the TH17 cell–Treg cell balance by TAZ.

Debbie Maizels/Springer Nature

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  1. Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Mandy J McGeachy

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  1. Mandy J McGeachy
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Correspondence to Mandy J McGeachy.

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The author declares no competing financial interests.

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McGeachy, M. A Hippo in the Fox(p3) house. Nat Immunol 18, 709–711 (2017). https://doi.org/10.1038/ni.3769

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