The short-chain fatty acids (SCFAs) acetate and butyrate, which are released from specialized diets by gut microbes, protect non-obese diabetic (NOD) mice against insulitis and slow the progression of diabetes.
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Acknowledgements
This work was supported by the NIH (DK092882, DK100500 and P30DK045735 to L.W.), JDRF (F.S.W.; 1-INO-2015-136 to L.W.), ADA (1-14-BS-222 to L.W.), the UK Medical Research Council (MR/K021141/1 to F.S.W.), Diabetes UK (to F.S.W.), the European Foundation for the Study of Diabetes (F.S.W.) and the British Council (F.S.W.).
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Wen, L., Wong, F. Dietary short-chain fatty acids protect against type 1 diabetes. Nat Immunol 18, 484–486 (2017). https://doi.org/10.1038/ni.3730
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DOI: https://doi.org/10.1038/ni.3730
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