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Gene-enhancer variants reveal diverse TCR-mediated differentiation

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The transcription factor IRF4 acts as a 'rheostat' for TCR signaling. Discrete levels of IRF4 can activate distinct transcriptional programs in T cells due to binding sites of variable affinity in groups of target genes.

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Figure 1: Variable TCR signaling and BATF–IRF4 abundance control distinct gene-expression patterns in differentiating T cells.

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Authors and Affiliations

  1. Michael P. Gallagher and Leslie J. Berg are in the Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.,

    Michael P Gallagher & Leslie J Berg

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  1. Michael P Gallagher
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  2. Leslie J Berg
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Correspondence to Leslie J Berg.

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Gallagher, M., Berg, L. Gene-enhancer variants reveal diverse TCR-mediated differentiation. Nat Immunol 18, 483–484 (2017). https://doi.org/10.1038/ni.3729

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