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IRE1 gives weight to obesity-associated inflammation

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IRE1α is a stress sensor that is activated by a high-fat diet. In adipose-tissue macrophages, it serves as a major switch toward pro-inflammatory M1 polarization and thereby contributes to obesity and associated diseases.

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Figure 1: IRE1α that is within ATMs and has been activated by a high-fat diet contributes to the pathology of obesity.

Katie Vicari/ Springer Nature

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Authors and Affiliations

  1. Bojan Bujisic and Fabio Martinon are in the Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.,

    Bojan Bujisic & Fabio Martinon

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  1. Bojan Bujisic
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  2. Fabio Martinon
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Correspondence to Fabio Martinon.

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The authors declare no competing financial interests.

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Bujisic, B., Martinon, F. IRE1 gives weight to obesity-associated inflammation. Nat Immunol 18, 479–480 (2017). https://doi.org/10.1038/ni.3725

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