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γδ T cells get adaptive

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Throughout ontogeny, the γδ TCR repertoire in human blood becomes less diverse and more focused, yet is private in nature, and specific adult γδ T cell subsets undergo substantial clonal expansion after challenge with cytomegalovirus.

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Figure 1: Focusing of the human γδ T cell repertoire.

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Authors and Affiliations

  1. Bruno Silva-Santos is with the Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.,

    Bruno Silva-Santos

  2. Jessica Strid is in the Division of Immunology and Inflammation, Department of Medicine, Imperial College London, London, UK.,

    Jessica Strid

Authors
  1. Bruno Silva-Santos
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  2. Jessica Strid
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Correspondence to Jessica Strid.

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Competing interests

B.S.-S. is co-founder and shareholder of Lymphact—Lymphocyte Activation Technologies SA.

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Silva-Santos, B., Strid, J. γδ T cells get adaptive. Nat Immunol 18, 370–372 (2017). https://doi.org/10.1038/ni.3705

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