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iNKT cells do a fat lot of good

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Altered signaling via the T cell antigen receptor (TCR) promotes an adipose-tissue-like phenotype in invariant natural killer cells (iNKT cells) during thymic development and causes selective enrichment for iNKT cells in adipose tissues.

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Figure 1: Alternative models for the development of adipose-resident iNKT cells.

Marina Corral Spence/ Springer Nature

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Authors and Affiliations

  1. Jayati Mookerjee-Basu and Dietmar J. Kappes are with the Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.,

    Jayati Mookerjee-Basu & Dietmar J Kappes

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  1. Jayati Mookerjee-Basu
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  2. Dietmar J Kappes
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Correspondence to Dietmar J Kappes.

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Mookerjee-Basu, J., Kappes, D. iNKT cells do a fat lot of good. Nat Immunol 18, 10–12 (2017). https://doi.org/10.1038/ni.3639

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