Skip to main content
SpringerLink
Log in

How lymphocytes add up

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

A surprising molecular mechanism underlying signal integration and programmed proliferation in adaptive immunity has been identified: the cell-cycle regulator Myc enables a lymphocyte to add up the strength of signals it receives and time its response accordingly.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Myc expression quantitatively regulates the program of lymphocyte proliferation in response to multiple signals.

References

  1. van Stipdonk, M.J., Lemmens, E.E. & Schoenberger, S.P. Nat. Immunol. 2, 423–429 (2001).

    Article  CAS  Google Scholar 

  2. Badovinac, V.P., Porter, B.B. & Harty, J.T. Nat. Immunol. 3, 619–626 (2002).

    Article  CAS  Google Scholar 

  3. Kaech, S.M. & Ahmed, R. Nat. Immunol. 2, 415–422 (2001).

    Article  CAS  Google Scholar 

  4. Wong, P. & Pamer, E.G. J. Immunol. 166, 5864–5868 (2001).

    Article  CAS  Google Scholar 

  5. Marchingo, J.M. et al. Science 346, 1123–1127 (2014).

    Article  CAS  Google Scholar 

  6. Heinzel, S. et al. Nat. Immunol. 18, 96–103 (2017).

    Article  CAS  Google Scholar 

  7. Hawkins, E.D., Turner, M.L., Dowling, M.R., van Gend, C. & Hodgkin, P.D. Proc. Natl. Acad. Sci. USA 104, 5032–5037 (2007).

    Article  CAS  Google Scholar 

  8. Duffy, K.R. et al. Science 335, 338–341 (2012).

    Article  CAS  Google Scholar 

  9. Gerlach, C. et al. Science 340, 635–639 (2013).

    Article  CAS  Google Scholar 

  10. Buchholz, V.R. et al. Science 340, 630–635 (2013).

    Article  CAS  Google Scholar 

  11. Smith, D.P., Bath, M.L., Metcalf, D., Harris, A.W. & Cory, S. Blood 108, 653–661 (2006).

    Article  CAS  Google Scholar 

  12. Lahoz-Beneytez, J. et al. Blood 127, 3431–3438 (2016).

    Article  CAS  Google Scholar 

  13. Mohri, H. et al. J. Exp. Med. 194, 1277–1287 (2001).

    Article  CAS  Google Scholar 

  14. den Braber, I. et al. Immunity 36, 288–297 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Becca Asquith is in the Department of Medicine, Imperial College London, London, UK.,

    Becca Asquith

  2. Rob J. de Boer is with Theoretical Biology and Bioinformatics, Utrecht University, the Netherlands.,

    Rob J de Boer

Authors
  1. Becca Asquith
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rob J de Boer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Becca Asquith.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Asquith, B., de Boer, R. How lymphocytes add up. Nat Immunol 18, 12–13 (2017). https://doi.org/10.1038/ni.3636

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3636

  • Springer Nature America, Inc.

Search

Navigation