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Resident memory T cells are a Notch above the rest

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Notch signaling promotes the maintenance of lung-resident CD8+ memory T cells that are transcriptionally poised for rapid effector responses but have heightened expression of inhibitory receptors, suggestive of tight regulation.

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Figure 1: Human lung memory CD8+ T cells have now been shown to bear properties of TRM cells.

Katie Vicari/ Nature Publishing Group

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Correspondence to David Masopust.

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Wijeyesinghe, S., Masopust, D. Resident memory T cells are a Notch above the rest. Nat Immunol 17, 1337–1338 (2016). https://doi.org/10.1038/ni.3617

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