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Phagocyte mayHEME caused by severe hemolysis

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Free heme released by hemolysis directly inhibits bacterial phagocytosis by macrophages via alterations of actin cytoskeletal dynamics.

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Figure 1: Excess free heme perturbs the cytoskeletal dynamics of phagocytes, which results in the inhibition of phagocytosis and migration.

Kim Caesar/Nature Publishing Group

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Author information

Authors and Affiliations

  1. Sioh-Yang Tan is with the Immune Imaging Program, Centenary Institute for Cancer Medicine and Cell Biology, Newtown, Australia,

    Sioh-Yang Tan

  2. The University of Sydney Medical School, Sydney, Australia.,

    Sioh-Yang Tan

  3. Wolfgang Weninger is with the Immune Imaging Program, Centenary Institute for Cancer Medicine and Cell Biology, Newtown, Australia,

    Wolfgang Weninger

  4. The University of Sydney Medical School, Sydney, Australia,

    Wolfgang Weninger

  5. the Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, Australia.,

    Wolfgang Weninger

Authors
  1. Sioh-Yang Tan
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  2. Wolfgang Weninger
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Correspondence to Wolfgang Weninger.

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The authors declare no competing financial interests.

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Tan, SY., Weninger, W. Phagocyte mayHEME caused by severe hemolysis. Nat Immunol 17, 1335–1337 (2016). https://doi.org/10.1038/ni.3616

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