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Glioma and microglia, a double entendre

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Microglia are important facilitators of glioma proliferation and invasion. An important component of this process seems to be glioma-mediated suppression of microglial activation via S-nitrosylation of microglial caspase-3.

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Figure 1: Glioma-induced caspase-3-dependent signaling pathway of tumor-supportive microglia.

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Authors and Affiliations

  1. Department of Neurosurgery, Harvey Cushing Neuro-Oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Korneel Grauwet & E Antonio Chiocca

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  1. Korneel Grauwet
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  2. E Antonio Chiocca
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Correspondence to E Antonio Chiocca.

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The authors declare no competing financial interests.

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Grauwet, K., Chiocca, E. Glioma and microglia, a double entendre. Nat Immunol 17, 1240–1242 (2016). https://doi.org/10.1038/ni.3586

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