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Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells

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Follicular helper T cells (TFH cells) sequentially acquire the potential to secrete interleukin 21 (IL-21) and IL-4. The shift from secretion of IL-21 to that of IL-4 modifies the nature of the 'help' signals delivered by TFH cells to germinal center (GC) B cells.

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Figure 1: Sequential acquisition of the production of IL-21 and IL-4 by GC TFH cells.

Marina Corral Spence/Nature Publishing Group

References

  1. Weinstein, J.S. et al. Nat. Immunol. 17, 1197–1205 (2016).

    Article  CAS  Google Scholar 

  2. Crotty, S. Annu. Rev. Immunol. 29, 621–663 (2011).

    Article  CAS  Google Scholar 

  3. Spolski, R. & Leonard, W.J. Nat. Rev. Drug Discov. 13, 379–395 (2014).

    Article  CAS  Google Scholar 

  4. Tangye, S.G. Curr. Opin. Immunol. 34, 107–115 (2015).

    Article  CAS  Google Scholar 

  5. Howard, M. et al. J. Exp. Med. 155, 914–923 (1982).

    Article  CAS  Google Scholar 

  6. Dan, J.M. et al. J. Immunol. 197, 983–993 (2016).

    Article  CAS  Google Scholar 

  7. Havenar-Daughton, C. et al. J. Immunol. 197, 994–1002 (2016).

    Article  CAS  Google Scholar 

  8. Shulman, Z. et al. Science 345, 1058–1062 (2014).

    Article  CAS  Google Scholar 

  9. Chang, C.-H. et al. Cell 153, 1239–1251 (2013).

    Article  CAS  Google Scholar 

  10. Nurieva, R.I. et al. Immunity 29, 138–149 (2008).

    Article  CAS  Google Scholar 

  11. Reinhardt, R.L., Liang, H.-E. & Locksley, R.M. Nat. Immunol. 10, 385–393 (2009).

    Article  CAS  Google Scholar 

  12. Qi, H., Cannons, J.L., Klauschen, F., Schwartzberg, P.L. & Germain, R.N. Nature 455, 764–769 (2008).

    Article  CAS  Google Scholar 

  13. Vinuesa, C.G., Linterman, M.A., Yu, D. & MacLennan, I.C.M. Annu. Rev. Immunol. 34, 335–368 (2016).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Simon Bélanger is in the Division of Vaccine Discovery, La Jolla Institute, La Jolla, California, USA.,

    Simon Bélanger

  2. Shane Crotty is in the Division of Vaccine Discovery, and the Department of Medicine, La Jolla Institute, La Jolla, California, USA, University of California San Diego, La Jolla, California, USA.,

    Shane Crotty

Authors
  1. Simon Bélanger
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  2. Shane Crotty
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Correspondence to Shane Crotty.

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Bélanger, S., Crotty, S. Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells. Nat Immunol 17, 1135–1136 (2016). https://doi.org/10.1038/ni.3561

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