Skip to main content

Advertisement

Log in

Cracking the code of skin inflammation with CD1a

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

CD1a on Langerhans cells in the epidermis is the lipid receptor for the plant-derived allergen urushiol and self lipids and is a key amplifier of inflammatory responses in urushiol-induced contact dermatitis as well as in psoriasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: CD1a presents lipid antigens and mediates urushiol-induced contact dermatitis and psoriasis.

References

  1. Kim, J.H. et al. Nat. Immunol. 17, 1159–1166 (2016).

    Article  CAS  Google Scholar 

  2. Kalish, R.S. & Johnson, K.L. J. Immunol. 145, 3706–3713 (1990).

    CAS  PubMed  Google Scholar 

  3. Kalish, R.S., Wood, J.A. & LaPorte, A. J. Clin. Invest. 93, 2039–2047 (1994).

    Article  CAS  Google Scholar 

  4. Wakabayashi, T. et al. Immunol. Cell Biol. 83, 18–24 (2005).

    Article  CAS  Google Scholar 

  5. Van Rhijn, I., Godfrey, D.I., Rossjohn, J. & Moody, D.B. Nat. Rev. Immunol. 15, 643–654 (2015).

    Article  CAS  Google Scholar 

  6. Moody, D.B. et al. Science 303, 527–531 (2004).

    Article  CAS  Google Scholar 

  7. de Jong, A. et al. Nat. Immunol. 11, 1102–1109 (2010).

    Article  CAS  Google Scholar 

  8. Kobayashi, C. et al. J. Invest. Dermatol. 132, 241–244 (2012).

    Article  CAS  Google Scholar 

  9. Nestle, F.O., Kaplan, D.H. & Barker, J. N. Engl. J. Med. 361, 496–509 (2009).

    Article  CAS  Google Scholar 

  10. Gudjonsson, J.E. et al. J. Invest. Dermatol. 129, 2795–2804 (2009).

    Article  CAS  Google Scholar 

  11. van der Fits, L. et al. J. Immunol. 182, 5836–5845 (2009).

    Article  CAS  Google Scholar 

  12. Schmidt, M. et al. Nat. Immunol. 11, 814–819 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Masayuki Amagai.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Amagai, M. Cracking the code of skin inflammation with CD1a. Nat Immunol 17, 1133–1134 (2016). https://doi.org/10.1038/ni.3557

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3557

  • Springer Nature America, Inc.

Navigation